Senior/Principal Bioinformatician
Our company culture is rooted in trust, inclusion, our capacity to collaborate, and our commitment to being honest and brave in our desire to successfully transform the lives of people with cancer.
Quantitative & Decision Sciences (QDS) is a multi-disciplinary team of data and analytics experts who drive purpose and consistency in how Adaptimmune collaborates and makes decisions through data. By Unlocking the value of our data, enabling analytics insights, and anticipating future needs, QDS optimizes identifying and answering the most important questions for our patients and products.
Within QDS, Bioinformatics is the business unit that focuses on data analytics and interpretation to support Research and Clinical Development programs across Adaptimmune. We are highly collaborative and support internal decision making, regulatory submissions, evaluation and benchmarking of available genomics datasets, tools, novel algorithm development and best practices.
PRIMARY RESPONSIBILITY
This role is a senior functional team member supporting Bioinformatics activities on assigned Research (e.g., Translational Sciences, Allogeneic), Enterprise Data & Analytics, and QDS projects, including contributions to milestone planning and delivery, data and knowledge stewardship, and internal and external publications and presentations.
KEY RESPONSIBILITIES
- Activities and Deliverables
- Typically splits time across roles as a team leader and team member, supporting multiple, concurrent projects across those roles
- Performs role-relevant activities including leading Bioinformatics contributions to the design of Translational and other Research projects and analysis plans; developing or contributing to multi-omics data analyses; organization and interpretation of sequencing and other genomic biomarker data analyses; authoring and/or critical review of functional specifications, scientific manuscripts and presentations, and other documents; contributions to data curation and quality
- If assigned as a business owner, provides business leadership for its development, deployment, adoption, lifecycle management, and support, in close collaboration with both customer functions (e.g., Research) and enabling functions (e.g., Information Management, Legal, Compliance), as appropriate
- Proactively ensures quality of her/his own work and completeness and accuracy of applicable quality and process documentation
- As needed, represents Bioinformatics/QDS and project teams at internal and external meetings as a senior functional expert, including audits, inspections, and regulatory/health authority interactions
- Individual Impact
- At all times, maintains clarity and understanding of her/his own role and responsibilities in the context of functional and project team activities
- Ensures own efforts adhere to applicable Adaptimmune and external requirements, and for others, strives to create clarity on those requirements in the context of project team activities
- Ensures good data and knowledge stewardship and inspection readiness on all assigned activities, as well as for team-level activities when assigned as a project lead
- Is a functional champion for Adaptimmune achieving and furthering our target enterprise data culture, and for self and within teams, promotes and practices data-driven decision making
- For QDS, cross-functional, and company initiatives, promotes their adoption and success, and when assigned, leads, or contributes as a project team resource
- At all times, ensures personal decisions, actions, and behaviors are consistent with Adaptimmune's Values and Code of Conduct
- Other duties as assigned in support of rapidly growing company
QUALIFICATIONS & EXPERIENCE
Required
- Graduate degree (Post Graduate preferred) in bioinformatics, computational biology, computer science, mathematics, life sciences, or a related field
- Demonstrated professional experience in bioinformatics, including organization, analysis, and interpretation of high-throughput (e.g., next generation sequencing) data and other multi-omics data
- Demonstrated hands-on experience performing relevant analyses using programming languages such as Python, R, or Perl, and in using relevant bioinformatics and data visualization tools and software
- Advanced to proficient knowledge of bioinformatics and genomics databases, resources, and public repositories
- Competent knowledge of oncology, immuno-oncology, or cell therapy clinical trials and analysis and interpretation of associated clinical patient data and endpoints
- Advanced understanding of practical regulatory, compliance, and patient privacy considerations in bioinformatics, such as HIPAA and GDPR
- Demonstrated experience working as a member of a project team in a cross-functional, multidisciplinary, or matrix project environment
Desirable
- Prior relevant experience with sequencing data analysis such as gene editing (Ion Torrent), single-cell RNA sequencing (scRNA-seq), RNA and DNA-sequencing
- Prior relevant bioinformatics experience in an industry setting (e.g., biotechnology, pharmaceutical, medical device, or other life science company)
- Competent knowledge of drug discovery, research, and development processes in a biotechnology or pharmaceutical industry setting
- Prior relevant experience leading functional project teams in a cross-functional or matrix project environment
- Experience developing and implementing business processes (e.g., SOPs, guidances) and training
- Relevant publications or scientific contributions in the field of bioinformatics
At Adaptimmune we embrace diversity and equality of opportunity. We believe that the more inclusive we are, the better our work will be. We welcome applications to join our team from all qualified candidates, regardless of age, colour, disability, marital status, national origin, race, religion, gender, sexual orientation, gender identity, veteran status or other legally protected category. It is our intent that all qualified applicants will receive equal consideration for employment.