Associate Scientist, Bioanalytical

Full Time On-Site/Hybrid Preclinical Research Scientist Apply for this Job Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Associate Scientist is joining Bioanalytical Development within the Clinical Pharmacology Department to primarily focus on bioanalytical sample analysis with the opportunity for method development and optimization, in support of preclinical and clinical development programs.

Responsibilities

• Perform routine non-GxP and GxP quantitative bioanalysis in a variety of biological matrices (fluids and tissues) in support of toxicokinetics, pharmacokinetics and biodistribution studies
• Follow SOPs and stay up to date on regulations
• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management and cross-functional teams
• Perform data analysis and interpretation
• Conduct peer review of data
• Present findings in team meetings
• Setup and maintain lab instrumentation
• Evaluate assay and instrument performance, ability to troubleshoot minor issues
• Maintain a well-documented laboratory notebook
• Effectively manage workload with minimal supervision
• Adhere to safe laboratory practices
• Multi-task across several projects and manage time effectively to achieve results

Requirements:

• Minimum BS degree with 2+ years of experience in the pharmaceutical/CRO industry
• Experience in a GxP environment performing sample analysis
• Demonstrated project and time management
• Good documentation practices with excellent organization and attention to detail
• Excellent oral and written communication skills
• Self-motivated team player with the ability to thrive in a fast-paced, dynamic, multi-disciplinary, matrixed environment

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Wisconsin pay range

$50,000—$90,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.