Scientist/Sr. Scientist, Bioanalytical
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
The Scientist/Sr. Scientist is joining Bioanalytical Development within the Clinical Pharmacology Department. The successful candidate will primarily focus on bioanalytical method development and qualification, and sample analysis in support of preclinical and clinical development programs. The Scientist/Sr. Scientist will have expertise with various analytical platforms and is well versed in bioanalysis. The Scientist/Sr. Scientist will lead bioanalytical training and provide expertise to less experienced scientists. The Scientist/Sr. Scientist will be joining a team of highly motivated and experienced scientists and will contribute to the success of Arrowhead programs.
Responsibilities
- Lead method development and qualification of various bioanalytical assays via HPLC-FL, LC-MS/MS and immunoassays for preclinical TK, PK and biodistribution studies and clinical PK and biomarker studies
- Perform quantitative analysis of oligonucleotides and its metabolites in a variety of biological matrices (fluids and tissues)
- Lead assigned projects, provide oversight of non-GxP and GxP bioanalytical method validations and sample analysis from early to late development, internally and externally
- Track progress against project timelines, generate regular status updates, and communicate progress and issues to management and cross-functional teams
- Follow SOPs and stay up to date on regulations
- Present findings in team meetings
- Train other group members in bioanalytical method development, qualification, analysis and project oversight
- Explore new analytical platforms for the group and lead lab organization and setup
- Perform data analysis and interpretation
- Conduct peer review of data
- Setup and maintain lab instrumentation
- Evaluate assay and instrument performance, ability to troubleshoot minor issues
- Maintain a well-documented laboratory notebook
- Effectively manage workload with minimal supervision
- Adhere to safe laboratory practices
- Multi-task across several projects and manage time effectively to achieve results
Requirements:
- B.S in Chemistry (or related field) with 8+ years of relevant GxP experience, M.S. in Chemistry (or related field) with 6+ years of relevant GxP experience, Ph.D. in Chemistry (or related field) with 2-5 years of relevant GxP experience
- Demonstrated method development experience with various analytical platforms and deep expertise with LC-MS/MS and immunoassays
- Demonstrated project and time management
- Experience with training other scientists and leading lab organization and processes
- Good documentation practices with excellent organization and attention to detail
- Demonstrated innovation, creativity and resilience in problem solving
- Excellent oral and written communication skills
- Self-motivated team player with the ability to thrive in a fast paced, dynamic, multi-disciplinary, matrixed environment
#LI-ONSITE
Wisconsin pay range
$90,000—$140,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.