Sr. Scientist, DMPK

Full Time On-Site/Hybrid Preclinical Research Scientist Apply for this Job Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking a seasoned DMPK Scientist. S/He will be joining a team of highly motivated and experienced chemists and biologists and contribute to the success of Arrowhead.

Responsibilities

• Develop in vitro and preclinical development DMPK strategies for nominated compounds across multiple indications and dose routes
• Manage DMPK function including both in-house resources and CROs
• Design, supervise and execute preclinical PK studies
• Provide discovery project teams with PK/PD expertise
• Oversee preclinical PK data analysis, interpretation, and reporting
• Develop IND enabling preclinical DMPK plans to meet regulatory expectations
• Execution of non-compartmental analysis using Phoenix WinNonlin software
• Assist in toxicokinetic study design, data analysis, and reporting
• Oversee metabolite identification from preclinical and clinical samples

Requirements:

• PhD in Pharmacometrics, Drug Metabolism, Pharmaceutical Science, or a related discipline with at least 5 years of industry experience
• Deep expertise in all areas of DMPK, knowledge of nucleotide drugs desired
• Direct hands-on experience and strong trouble shooting skills with in vitro assays, in vivo studies, and Phoenix WinNonlin software
• Extensive experience with drug development and knowledge of regulatory processes
• Experienced with FDA regulatory guidance and communications
• A strong track record of accomplishments
• Excellent interpersonal, verbal and written communication skills

Wisconsin pay range

$100,000—$160,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.